Investigating the Inhibition Effect of Portulaca oleracea against SARS-CoV-2 through Molecular Docking Simulation

Recently a new virus strain designated as SARS coronavirus result in fatal pandemic known COVID-19. Bioinformatics and drug screening are directed for the assessment of potential inhibitors before their clinical implementation treatment this pneumonia. One expected natural potent is Portulaca oleracea which has been assigned an effective to different human ailments throughout whole world. P. widely spread most areas Egypt. In current study, hydrophilic polysaccharides were purified from extracts. Molecular docking simulation implemented investigate antiviral effect inhibit The viral protease was downloaded Protein Data Bank (PDB# 6y84) then docked with inhibitors. results indicate that can bind tightly SARS-CoV-2 protease, indicates inhibitor